Research: Help for Drug Resistant Gonorrhea

Plants to the Rescue

I posted on a new strain of Gonorrhea that is resistant to all currently known antibiotics, click here for the article.  The following abstract highlights several plants that have a level of efficacy in the treatment of Neisseria gonorrhea.

Extracts of Canadian first nations medicinal plants, used as natural products, inhibit neisseria gonorrhoeae isolates with different antibiotic resistance profiles.

Background: Neisseria gonorrhoeae (Ng) has developed resistance to most antimicrobial agents and the antibiotics recommended for therapy are restricted, for the most part, to third generation cephalosporins. In order to investigate new potential sources of antimicrobial agents, the antibacterial properties of 14 Canadian plants used in traditional First Nations’ medicine were tested against Ng isolates having differing antimicrobial susceptibility profiles.

Methods: Ethanolic extracts of 14 Canadian botanicals, analyzed by high-performance liquid chromatography, were tested for their antimicrobial activity (disc diffusion and/or agar dilution assays) against susceptible Ng reference strains and a panel of 28 Ng isolates with various antimicrobial resistance profiles.

Results:
Extracts of Arctostaphylos uva ursi (kinnikinnick or bearberry),
Hydrastis canadensis (goldenseal),
Prunus serotina (black cherry), and
Rhodiola rosea (roseroot) inhibited the growth of all Ng isolates with minimum inhibitory concentrations of 32 ?g/mL, 4 to 32 ?g/mL, 16 to >32 ?g/mL, and 32 to 64 ?g/mL, respectively.

Extracts of Acorus americanus (sweet flag),
Berberis vulgaris (barberry),
Cimicifuga racemosa (black cohosh),
Equisetum arvense (field horsetail),
Gaultheria procumbens (wintergreen),
Ledum groenlandicum (Labrador tea),
Ledum palustre (marsh Labrador tea), Oenothera biennis (common evening primrose), Sambucus nigra (elderberry), and
Zanthoxylum americanum (prickly ash) had weak or no antimicrobial activity against the Ng isolates with minimum inhibitory concentrations ?256 ?g/mL.

The phytochemical berberine from H. canadensis inhibited the growth of all Ng isolates.
The phytochemicals, salidroside and rosavin, present in R. rosea, also showed inhibitory activity against Ng strains.

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Conclusion: Canadian botanicals represent a potential source of novel compounds which inhibit Ng, including isolates resistant to antibiotics.

 

Source: Journal of Sexually Transmitted Diseases 2011 Jul;38(7):667-71

Expensive Health Care, Producing Poor Results

What an interesting report! Although the United States spends more on health care, the results are not coming through. IMHO it could have something to do with a need for including holistic medicine in the health care system. Health is also about the whole person. However, a few American hospitals are enlarging their scope to be more inclusive (click here) of holistic approaches in health care. Let’s hope more come on board.

US ranks last among 7 countries on health system performance

Affordable Care Act holds promise for US performance; focus on information technology and primary care vital to achieving high performance

New York, NY, June 23, 2010—Despite having the most expensive health care system, the United States ranks last overall compared to six other industrialized countries—Australia, Canada, Germany, the Netherlands, New Zealand, and the United Kingdom—on measures of health system performance in five areas: quality, efficiency, access to care, equity and the ability to lead long, healthy, productive lives, according to a new Commonwealth Fund report. While there is room for improvement in every country, the U.S. stands out for not getting good value for its health care dollars, ranking last despite spending $7,290 per capita on health care in 2007 compared to the $3,837 spent per capita in the Netherlands, which ranked first overall.

Provisions in the Affordable Care Act that could extend health insurance coverage to 32 million uninsured Americans have the potential to promote improvements to the United States’ standing when it comes to access to care and equity, according to Mirror Mirror On The Wall: How the Performance of the U.S. Health Care System Compares Internationally 2010 Update, by Commonwealth Fund researchers Karen Davis, Cathy Schoen, and Kristof Stremikis. The United States’ low marks in the quality and efficiency dimensions demonstrate the need to quickly implement provisions in the new health reform law and stimulus legislation that focus on realigning incentives to reward higher quality and greater value, investment in preventive care, and expanding the use of health information technology.

“It is disappointing, but not surprising that, despite our significant investment in health care, the U.S. continues to lag behind other countries,” said Commonwealth Fund President and lead author Karen Davis. “With enactment of the Affordable Care Act, however, we have entered a new era in American health care. We will begin strengthening primary care and investing in health information technology and quality improvement, ensuring that all Americans can obtain access to high quality, efficient health care.”

Earlier editions of the report, produced in 2004, 2006, and 2007, showed similar results. This year’s version incorporates data from patient and physician surveys conducted in seven countries in 2007, 2008, and 2009.

Key findings include:

On measures of quality the United States ranked 6th out of 7 countries. On two of four measures of quality—effective care and patient-centered care—the U.S. ranks in the middle (4th out of 7 countries). However, the U.S. ranks last when it comes to providing safe care, and next to last on coordinated care. U.S. patients with chronic conditions are the most likely to report being given the wrong medication or the wrong dose of their medication, and experiencing delays in being notified about an abnormal test result.

On measures of efficiency, the U.S ranked last due to low marks when it comes to spending on administrative costs, use of information technology, re-hospitalization, and duplicative medical testing. Nineteen percent of U.S. adults with chronic conditions reported they visited an emergency department for a condition that could have been treated by a regular doctor, had one been available, more than three times the rate of patients in Germany or the Netherlands (6%).

On measures of access to care, people in the U.S. have the hardest time affording the health care they need—with the U.S. ranking last on every measure of cost-related access problems. For example, 54 percent of adults with chronic conditions reported problems getting a recommended test, treatment or follow-up care because of cost. In the Netherlands, which ranked first on this measure, only 7 percent of adults with chronic conditions reported this problem.

On measures of healthy lives, the U.S. does poorly, ranking last when it comes to infant mortality and deaths before age 75 that were potentially preventable with timely access to effective health care, and second to last on healthy life expectancy at age 60.

On measures of equity, the U.S. ranks last. Among adults with chronic conditions almost half (45%) with below average incomes in the U.S. reported they went without needed care in the past year because of costs, compared with just 4 percent in the Netherlands. Lower-income U.S. adults with chronic conditions were significantly more likely than those in the six other countries surveyed to report not going to the doctor when they’re sick, not filling a prescription, or not getting recommended follow-up care because of costs.

Methodology

Data are drawn from the Commonwealth Fund 2007 International Health Policy Survey, conducted by telephone in Australia, Canada, Germany, the Netherlands, New Zealand, the United Kingdom, and the United States; the 2008 International Health Policy Survey of Sicker Adults, conducted in the same seven countries plus France; the Commonwealth Fund 2009 International Health Policy Survey of Primary Care Physicians, conducted in the same eight countries plus Italy, Norway, and Sweden; the Organization for Economic Cooperation and Development Health Data 2009; and World Health Organization mortality and population statistics for 2002-03. The 2007 Commonwealth Fund survey focuses on the primary care experiences of nationally representative samples of adults ages 18 and older in the seven countries. The 2008 survey targets a representative sample of “sicker adults,” defined as those who rated their health status as fair or poor, had a serious illness in the past two years, had been hospitalized for something other than a normal delivery, or had undergone major surgery in the past two years. The 2009 survey looks at the experiences of primary care physicians.

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The Commonwealth Fund is a private foundation supporting independent research on health policy reform and a high performance health system.

Boy Born with 15 Fingers and 16 Toes

A six-year-old boy with 15 fingers and 16 toes has undergone surgery to remove his extra digits. The unnamed Chinese child had four fingers on one hand and three on the other fused together.

He now has ten fingers and ten toes following a six-and-a-half hour operation at a hospital in Shenyang, Liaoning, to remove the surplus 11 digits. The story is here the photos are amazing. Although it is not that unusual to have extra digits, this is most ever recorded.

Research: Inexpensive Method for Stroke Detection

Is this the kind of innovation that American health care needs?
Small study demonstrates possibilities of reducing unnecessary MRI tests and improving safety

September 18, 2009-In a small “proof of principle” study, stroke researchers at Johns Hopkins and the University of Illinois have found that a simple, one-minute eye movement exam performed at the bedside worked better than an MRI to distinguish new strokes from other less serious disorders in patients complaining of dizziness, nausea and spinning sensations.

Results of the study of 101 patients , who were already at higher than normal risk of stroke because of factors including high blood pressure or high cholesterol, were published online ahead of print on Sept. 17 in Stroke. The patients were all seen at OSF St. Francis Medical Center in Peoria, Ill.

The project, spearheaded by a Johns Hopkins neurologist in collaboration with colleagues at the University of Illinois in Peoria, found that the quick, extremely low-cost exam caught more strokes than the current gold standard of MRI, suggesting that if further research on broader populations confirms these results, physicians may have a way to improve care and avoid the high costs of MRI in some cases.

“The idea that a bedside exam could outperform a modern neuroimaging test such as MRI is something that most people had given up for dead, but we’ve shown it’s possible,” says David E. Newman-Toker, M.D., Ph.D., assistant professor of neurology at the Johns Hopkins University School of Medicine.

Dizziness is a common medical problem, Newman-Toker says, responsible for 2.6 million emergency room visits annually in the United States. While the vast majority of dizziness complaints are caused by benign inner-ear balance problems, about 4 percent are signals of stroke or transient ischemic attack (TIA, a condition that often warns of impending stroke in the coming days or weeks). Because more than half of patients with dizziness who are experiencing strokes show none of the classic stroke symptoms — one-sided weakness, numbness, or speech problems — emergency room physicians are estimated to misdiagnose at least a third of them, losing the chance for quick and effective treatment.

“We know that time is brain, so when patients having a stroke are sent home erroneously, the consequences can be really serious, including death or permanent disability,” says Jorge C. Kattah, M.D., chairman of neurology at OSF St. Francis Medical Center, who co-led the study.

The study of eye movement tests was suggested by previous research showing that people experiencing a stroke have eye-movement alterations that correlate with stroke-damage to various brain areas and that these are distinct from eye-movement alterations seen with benign ear diseases. Some patients, for example, can’t immediately adjust their eye position if their heads are quickly turned to the side, or they experience jerky eye movements as they try to focus on a doctor’s finger when looking to either side.

Newman-Toker and his colleagues at the University of Illinois College of Medicine in Peoria wondered whether testing eye movements in dizzy patients might help them sort out which ones were having a stroke from those with other problems.

All of the patients in the current study were seen after complaining of severe dizziness that had lasted for several hours continuously, and all had at least one risk factor for stroke. The researchers selected them to increase the chance that they would find strokes in this population. None of the patients had a history of previous dizzy spells and more than half sought care at the Peoria medical center’s ER, though some were inpatients at the hospital or were transferred from other area hospitals.

The researchers gave each patient an exam comprised of three eye-movement tests: looking for inability to keep the eyes stable as patients heads were rotated rapidly to either side, looking for jerkiness as patients tracked a doctor’s finger to look right and left, and checking eye position to see if one eye was higher than the other. Each patient then received an early MRI, the highest-quality neuroimaging test available to confirm stroke in dizzy patients. Patients with eye tests suggesting stroke but without stroke on the first MRI scan underwent a repeat scan.

In the end, 69 patients were diagnosed with stroke and 25 with inner-ear conditions. The remainder had other neurological problems. Using only the three eye-movement tests, the researchers had correctly diagnosed all of the strokes and 24 of 25 with inner-ear conditions. By contrast, initial MRI scans were falsely negative in eight of the 69 stroke patients, who were later correctly diagnosed with follow-up MRIs.

Though the researchers emphasize the need to verify their results in a larger and more general population of patients with dizziness, Newman-Toker says the initial findings are “incredibly promising.” If they hold true, he adds, testing eye movements could have several advantages over MRI beyond reliable diagnostics. For example, while the wait time for an MRI can be several hours or more, physicians can perform all three eye-movement tests in a minute or less. Also, the eye-movement tests are “basically free,” compared to $1000 or more for an MRI, Newman-Toker says.

“In an era where cost containment is butting up against issues of quality in health care delivery, there’s tremendous potential for bedside approaches like ours that could reduce costs while improving quality at the same time,” says Newman-Toker.

For more information, go here

Research: Sex Chip that stimulates pleasure center in brain

Scientists are developing an electronic ‘sex chip’ that works by stimulating the pleasure centres in the brain.
The technology, which creates tiny shocks deep in the brain, has already been used in America to treat Parkinson’s disease.

Now researchers are focusing on the orbitofrontal cortex, which is associated with feelings of pleasure caused by eating and sex.

A research survey conducted by Morten Kringelbach, a fellow at Oxford University, found the orbitofrontal cortex could be a ‘new stimulation target’ to help people with anhedonia – an inability to experience pleasure from such activities.

His colleague Professor Tipu Aziz said: ‘There is evidence that this chip will work.

‘A few years ago a scientist implanted such a device into the brain of a woman with a low sex drive and turned her into a very sexually active woman. She didn’t like the sudden change, so the wiring in her head was removed.’
But Professor Aziz said the present surgery needed to implant the wire in the brain was ‘intrusive and crude’ and would need about 10 years worth of development.

‘When the technology is improved, we can use deep brain stimulation in many new areas. It will be more subtle, with more control over the power so you may be able to turn the chip on and off when needed.’
An electronic machine that creates sexual feelings is already being developed in America by Dr Stuart Meloy. He calls his device, which is a modified spinal cord stimulator, the Orgasmatron. The name is taken from the 1973 Woody Allen film Sleeper. (article here)

Would You Like to Carry Your Medical Records…under your skin?

What are you visioning for your health? Medical records embedded in your arm. Is this the future of health? Read on..

Microsoft wants to get under your skin

HealthVault links up with VeriMed RFID chips

Bill Ray / The Register | December 15, 2008

Microsoft’s HealthVault, the medical records database, is to be integrated with VeriMed’s human-embedded RFID tags, allowing doctors to access the medical records of unconscious patients with a quick scan of the arm.

VeriMed consists of an RFID tag that is embedded in the arm of a hopefully willing participant, and responds with a 16-digital identity code when queried at 134KHz. This code can then be used to identify the person through VeriChip’s website, and will soon be able to link to their medical records as stored on Microsoft’s HealthVault system.

“VeriMed adds an exciting RFID-based option for HealthVault users trying to keep themselves and their families safe,” says Sean Nolan, the chief architect for HealthVault, quoted in RFID Journal. If you’re excited about the idea of being electronically indexed then this is probably the technology for you.

Not that the future of VeriMed is in any way certain, despite the Microsoft link. The company’s parent, VeriChip, has already tried to sell off the human-implanting part of the business as punters prove remarkably reluctant to be serial-numbered. Should the business fail entirely, a connection to HealthVault could be the best hope for the poor souls who’ve already succumbed to having chips embedded in their arms.

Study Suggest Some Cancers May Go Away

Study Suggests Some Cancers May Go Away
November 25, 2008, New York Times
http://www.nytimes.com/2008/11/25/health/25breast.html

Cancer researchers have known for years that it was possible in rare cases for some cancers to go away on their own. There were occasional instances of melanomas and kidney cancers that just vanished. And neuroblastoma, a very rare childhood tumor, can go away without treatment. But these were mostly seen as oddities – an unusual pediatric cancer that might not bear on common cancers of adults, a smattering of case reports of spontaneous cures. And since almost every cancer that is detected is treated, it seemed impossible even to ask what would happen if cancers were left alone. Now, though, researchers say they have found a situation in Norway that has let them ask that question about breast cancer. And their new study, to be published Tuesday in The Archives of Internal Medicine, suggests that even invasive cancers may sometimes go away without treatment and in larger numbers than anyone ever believed. Robert M. Kaplan, the chairman of the department of health services at the School of Public Health at the University of California, Los Angeles, [is] persuaded by the analysis. The implications are potentially enormous, Dr. Kaplan said. If the results are replicated, he said, it could eventually be possible for some women to opt for so-called watchful waiting, monitoring a tumor in their breast to see whether it grows. “People have never thought that way about breast cancer,” he added. Dr. Kaplan and his colleague, Dr. Franz Porzsolt, an oncologist at the University of Ulm, said in an editorial that accompanied the study, “If the spontaneous remission hypothesis is credible, it should cause a major re-evaluation in the approach to breast cancer research and treatment.”

Note: For reports from major media sources on many hopeful new developments in the battle against cancer, click here.

Diverticulitis Research on Eating Nuts, Seeds and Popcorn

Diverticulitis is an inflammatory condition of diverticulosis. Diverticulosis is the condition of pouches, like outcroppings, developing usually in the lower portion of the large intestine also known as the sigmoid colon. The inflammatory condition may produce abdominal pain. Pain in the lower left abdominal quadrant is suggestive of diverticulitis.

Who Gets Diverticulosis?

The condition is common for those over 40 and by the age of 60 at least half of the population has this complaint. It is more common in men than women.

Dietary Considerations

Patients with this condition are often advised to avoid nuts, popcorn, seeds. A recent study of 47, 228 men was reported in the Journal of the American Medical Association. It showed that there is no increased risk of eating of diverticulosis as a result of eating the formerly forbidden foods. The report suggests that the recommendation to avoid these foods to prevent complications should be reconsidered.

Anthropological studies show that cultures where people eat high fiber diets rarely have gastrointestinal disorders. These disorders are more common in diets high in meat, white flour products and dairy.

Healing Suggestions

If your doctor informs you that you have this condition, get to work! Let the healing begin. Nothing comes out of the “blue”. Learn to listen to your body. How do you feel after you eat? Are you irritable, sluggish, weak or angry?

  • Examine your diet.
  • Move more.
  • Reduce the size of your waist. Several studies have indicated that a trim waist (waist-hip ration) is indicative of reduced risk of developing certain chronic diseases.
  • Whole grains
  • Vegetables
  • Legumes

P.S. Those in the natural health arena of all stripes were already aware of the causes of this condition and how to prevent it. It will be really wonderful when all healers will be able to work together to help heal the sick.

A New HBP Drug – Cleviprex

A novel high blood pressure drug has been approved by the FDA. It is injectable. It may be useful as as an acute hypertensive treatment as drug studies suggest. “Novel” and new drugs may rouse cheers in stockholders but the public continues to be one huge test market with those injured deemed “acceptable risks.” Doctors primarily learn about drugs and medications from the pharmaceutical industry. And the public at times is left in the dark as to what these substances are and what side effects they produce which may cause harm.

For information about dihydropyridine calcium channel blockers read here
About Cleviprex:(from Medical News)

Cleviprex is a novel, investigational drug rationally designed to meet the needs of the acute care practitioner for an intravenous hypertensive agent. It is the first third-generation dihydropyridine calcium channel blocker that acts rapidly and reliably, is vascular- and arterial-selective, and has an ultrashort half-life. Cleviprex recently completed Phase III clinical trials.

Approval was based on clinical studies involving 1,406 people. The most common side effects were headache, nausea and vomiting, the company said.

Abstract

Dihydropyridine calcium antagonists play an important role in the treatment of hypertension and angina pectoris. They lower blood pressure by a well-characterized mechanism of blocking L-type calcium channels in smooth muscle cells. Additionally, there is growing evidence that dihydropyridines also modulate endothelial functions by other mechanisms, since macrovascular endothelial cells do not express L-type calcium channels. A number of studies have demonstrated that dihydropyridine calcium antagonists enhance bioavailability of endothelial nitric oxide (NO). (more)

A Number of Marketed Dihydropyridine Calcium Channel Blockers Have Mineralocorticoid Receptor Antagonist Activity (abstract link)
…our data suggest that, in addition to their calcium channel blocking activity, a number of dihydropyridine calcium channel blockers also have mineralocorticoid receptor antagonist activity at high doses, a finding which may thus prove useful for the design of novel antihypertensive drugs in the future.

ADHD and Heart Screening, Update

Apparently the experts are at odds with one another, but have come to some agreement regarding assessing the risk of future heart problems developing in children who take stimulant drugs.

Pediatricians don’t consider it necessary for heart screenings for children prescribed stimulant drugs. The American Heart Association initially recommended heart screening for children taking stimulant drugs. The current position is it not mandatory, but considering the number of children who have sudden cardiac death it may be useful to at least have the heart screen performed. The AHA has released an update clarifying their position, here. Basically an ECG screening is not considered mandatory.
U.S. News reported on this topic here
Following is the statement: of the American Heart Association
May 16, 2008

This statement replaces the April 21 news release

Endorsed by the American Academy of Child and Adolescent Psychiatry, the American College of Cardiology, Children and Adults with Attention-Deficit/Hyperactivity Disorder, the National Initiative for Children’s Healthcare Quality and the Society for Developmental and Behavioral Pediatrics

The American Heart Association released on April 21, 2008 a statement about cardiovascular evaluation and monitoring of children receiving drugs for the treatment of Attention Deficit Hyperactivity Disorder (ADHD). As a result of language in the news release and the statement as published, there have been conflicting interpretations of the recommendations regarding the use of an electrocardiogram (ECG) in assessing children with ADHD who may need treatment with medications. The purpose of this joint advisory of the American Academy of Pediatrics (AAP) and the American Heart Association (AHA) is to clarify the recommendations.

• The scientific statement included a review of data that show children with heart conditions have a higher incidence of ADHD.

• Because certain heart conditions in children may be difficult (even, in some cases, impossible) to detect, the AAP and AHA feel that it is prudent to carefully assess children for heart conditions who need to receive treatment with drugs for ADHD.

• Obtaining a patient and family health history and doing a physical exam focused on cardiovascular disease risk factors (Class I recommendations in the statement) are recommended by the AAP and AHA for assessing patients before treatment with drugs for ADHD.

• Acquiring an ECG is a Class IIa recommendation. This means that it is reasonable for a physician to consider obtaining an ECG as part of the evaluation of children being considered for stimulant drug therapy, but this should be at the physician’s judgment, and it is not mandatory to obtain one.

• Treatment of a patient with ADHD should not be withheld because an ECG is not done. The child’s physician is the best person to make the assessment about whether there is a need for an ECG.

• Medications that treat ADHD have not been shown to cause heart conditions nor have they been demonstrated to cause sudden cardiac death. However, some of these medications can increase or decrease heart rate and blood pressure. While these side effects are not usually considered dangerous, they should be monitored in children with heart conditions as the physician feels necessary.

The statement has been revised to clarify the language and to assure that the intent is clear to all readers. This is available at:
http://circ.ahajournals.org/cgi/reprint/CIRCULATIONAHA.107.189473

The correction notice is at:
http://circ.ahajournals.org/cgi/content/full/CIRCULATIONAHA.107.189473/DC1.

This clarification has been endorsed by the American Academy of Child and Adolescent Psychiatry, the American College of Cardiology, Children and Adults with Attention-Deficit/Hyperactivity Disorder, the National Initiative for Children’s Healthcare Quality and the Society for Developmental and Behavioral Pediatrics.

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