Category Archives: aging

B Vitamins, Can Help Your Aging Brain

B vitamins–B-6, B-12 and folate–all nourish the brain. But much remains to be discovered about the relation between these essential nutrients and our brainpower.

U.S. Department of Agriculture (USDA) nutritionist Lindsay H. Allen has collaborated in ongoing research that has taken a closer look at the role these nutrients may play in preventing decline in brain function. The investigations, led by Mary N. Haan of the University of California-San Francisco, are part of the multiyear Sacramento (Calif.) Area Latino Study on Aging, or “SALSA.” Begun in 1996, the study attracted nearly 1,800 Hispanic seniors, ages 60 to 101, as volunteers.

According to Allen, the research is needed because many studies of B vitamins and brain function have given inconsistent or conflicting results. Allen is director of the Agricultural Research Service (ARS) Western Human Nutrition Research Center in Davis, Calif. ARS is the chief intramural scientific research agency of USDA. Scientists from the University of California-Davis (UCD) and the UCD Medical Center also are collaborating in the research.

An analysis of volunteers’ blood samples showed that lower levels of one B vitamin, folate, were associated with symptoms of dementia and poor brain function, also called “cognitive decline,” as determined by standard tests of memory and other factors. The impairments were detectable even though less than 1 percent of the volunteers were actually deficient in folate.

In women, but not men, low levels of folate were associated with symptoms of depression. In fact, female volunteers whose plasma folate levels were in the lowest third were more than twice as likely to have symptoms of depression as volunteers in the highest third. That finding provided new evidence of an association between lower blood folate and depression. Depression is already known to affect brain function.

In research with vitamin B-12, the SALSA team determined that a protein known as holoTC, short for holotranscobalamin, might be key to a new approach for detecting cognitive decline earlier and more accurately.

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The researchers have published these and other findings, beginning in 2003 and continuing through this year, in the American Journal of Clinical Nutrition, Clinical Chemistry and Laboratory Medicine, The European Journal of Clinical Nutrition, The Journal of Nutrition, and The Journal of Nutrition, Health, and Aging.

Yoga Poses can prevent falls in the Elderly

Research out of Temple’s Gait Study Center suggests basic yoga exercises could help prevent falls in elderly women

A specific type of yoga can help improve stability and balance in women over age 65, which could help to prevent falls, finds a preliminary study out of Temple University’s Gait Study Center.

Dr. Jinsup Song and researchers at the School of Podiatric Medicine and the College of Health Professions examined the gait and postural stability of 24 elderly females who were enrolled in an Iyengar yoga program specifically designed for those over 65. They found that at the end of the nine-week program, participants had a faster stride, an increased flexibility in the lower extremities, an improved single-leg stance and increased confidence in walking and balance.

Song will present these findings at the Gait and Clinical Movement Analysis Society’s Annual Meeting on April 4.

The Centers for Disease Control and Prevention reports that among people 65 years and older, falls are the leading cause of nonfatal injuries and hospital admissions for trauma, and nearly one-third of older adults suffer from some type of fall each year.

Song and his researchers suggest that improving balance and stability through yoga could help reduce the risk of falling, as these are two areas that are often deficient when a fall occurs.

“We were very impressed at the progress our participants made by the end of the program,” said Song. “Subjects demonstrated improved muscle strength in lower extremities, which helps with stability. There was also a pronounced difference in how pressure was distributed on the bottom of the foot, which helps to maintain balance.”

Song and study coauthor Marian Garfinkel, Ed.D., a certified senior Iyengar Yoga instructor, consulted her mentor, renowned yoga master B.K.S. Iyengar, to craft a specific yoga program of poses tailored to the elderly who have had little to no yoga experience. The use of props in the Iyengar program allows participants to gradually master the poses while building their confidence level.

“In the past, similar studies have been done that look at gait and balance improvement in elderly females using a more aggressive form of yoga,” said Song, principal investigator and director of the Gait Study Center. “For this study, we worked to create a very basic regimen that taught participants proper ways to breathe, stand and pose.”

Before she started the program, Maryanne Brown wasn’t sure she’d even want to stick with it.

“I’ve never been one for exercise,” said the West Philadelphia native. “But I started attending the classes, and I thought, ‘Why not?’ I really did want to make an effort to get healthy, so I kept at it.”

Now, even after the program, Brown continues her regimen at the B.K.S. Iyengar Yoga Studio of Philadelphia, under the direction of Garfinkel, an adjunct associate professor at the School of Medicine.

“I feel more centered now. I have more confidence when I walk, and I’m able to walk further for longer periods of time,” Brown said.

Researchers also found that some participants, like Brown, who had unrelated back and knee pain at baseline, were pain-free by the end of the study.

“I’ve had that pain for years,” Brown said. “And during one session, I heard a ‘pop’ and was sure I wouldn’t be able to get up. But I did, and I felt better than I had in years.”

In addition to improving balance and stability, Song notes that participation in a group setting, such as an Iyengar yoga class, could have positive psychological effects for the elderly, as well.

“Throughout the program, participants consistently noted that they had a better outlook on their day-to-day lives,” he said. “The class gave them something to look forward to; they found it engaging, and said that if they couldn’t attend a class, they definitely missed it.”

“This program has been amazing,” said Brown, who now spends up to six hours a week practicing Iyengar yoga. “They’re really onto something with it. It’s made a tremendous difference in my quality of life.”

“The bottom line is, people want to stay active as long as possible,” Song said. “This can help elderly women maintain their mobility and independence, in several ways.”

Song noted that this preliminary information will pave the way for a larger study on how Iyengar yoga affects the function of the foot to improve balance and stability and prevent falls.

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Other researchers on this study are Roberta Newton, P.T., Ph.D., of Temple University’s College of Health Professions; and Ji Su Yun, B.A., Benjamin Heilman, M.S., and Emilie Zoltick, B.A., of the Gait Study Center at Tempe University. Funding was provided by the Office of the Vice President for Research and Development at Temple University.

10 Million Baby Boomers Face Alzheimer’s

An estimated 10 million American baby boomers will develop Alzheimer’s disease in their lifetime, placing enormous strains on the U.S. health-care system and the already overburdened network of caregivers, a new report predicts.

Currently, at least 5.2 million Americans suffer from Alzheimer’s, including 200,000 to 250,000 people under age 65. By 2010, projections say there will be 500,000 new cases of the mind-wasting disease each year, and nearly one million new cases annually by 2050, the report estimates.

In addition, the report, released Tuesday by the Alzheimer’s Association, showed that the disease is now the seventh deadliest in the nation and that women are at greater risk than men.

The overall prediction for 10 million, which translates to 1 out of every 8 boomers, is a number that is “particularly significant because it’s people who are now just approaching what we refer to as the age of highest risk,” said Stephen McConnell, the association’s vice president for advocacy and public policy.

The age of highest risk for Alzheimer’s starts at 65, McConnell said. “Some of these people are already developing the disease, and those numbers are just going to increase dramatically over the next several decades,” he added.

This is going to have a huge impact on baby boomers’ lives, their families, and the nation’s health-care system, McConnell said.

Right now, there are 10 million caregivers providing care, many of them family members, at enormous personal cost, McConnell noted. “These caregivers tend to be spouses, but there’s evidence that 250,000 of these caregivers are children 8 to 18,” he said. “So you get the sense of an expanded circle of people who are affected by this disease. It’s not just the person with the disease. It’s not just their immediate caregiver — it’s the children and grandchildren.”

Most people with Alzheimer’s are eligible for Medicare, so a burgeoning number of Alzheimer’s patients will put a major strain on the federal health insurance program, McConnell pointed out.

Medicare currently spends more than three times as much money on people with Alzheimer’s and other dementias than it does for the average Medicare recipient. In 2005, Medicare spent $91 billion on people with Alzheimer’s and other dementias. By 2010, that number is expected to climb to $160 billion, and by 2015, to $189 billion annually, according to the report.

These high Medicare costs occur because Alzheimer’s tends to complicate the treatment of other medical conditions such as diabetes and heart disease, McConnell said. Also, while people with Alzheimer’s live an average of eight years, they can live more than 20 years, placing an additional strain on the health-care system.

The projected rise in Alzheimer’s cases will also burden the long-term care system, McConnell said. “Right now, it’s mostly families providing care at home, but most people with Alzheimer’s disease end up in a nursing home or an assisted living facility,” he said. “In fact, three-quarters of people with Alzheimer’s will die in such a facility.”

Complicating matters, long-term care isn’t covered by most regular health insurance, and most people don’t have long-term care insurance, McConnell said. “That’s going to have a devastating impact on society,” he said.

Still, McConnell said there’s hope for new treatments for Alzheimer’s, but it’s going to take a lot more money for research and testing to make those hopes a reality.

There seems to be a connection between Alzheimer’s and cardiovascular disease, McConnell said. Diet, exercise and blood-pressure control may help stave off cognitive decline and Alzheimer’s, he said.

Also, new drugs being tested “show promise in altering the course of the disease,” McConnell said.

“Eventually, this disease could be preventable. It’s certainly a disease we hope will be manageable if we catch it early,” McConnell said. “If we are just able to slow the progression of the disease and delay its onset, it could save many millions of people from having to deal with the consequences of the disease. And it could save billions of dollars in the health-care system.”

But, the U.S. government has cut spending on Alzheimer’s research, McConnell added. “Right now the government is spending about $640 million a year on Alzheimer’s research,” he said. “It seems like a lot, but we are spending over $5 billion a year on cancer, and more than $3 billion on heart disease each year. If we can just get that $640 million up to $1 billion a year, that would make a big difference.”

Dr. Gary Kennedy, director of geriatric psychiatry at Montefiore Medical Center in New York City, worries that there won’t be enough trained medical professionals to deal with the projected rise in Alzheimer’s patients.

“We are not training enough generalists or specialists in geriatrics, whether it’s medicine, psychiatry, family medicine, nursing or social work in the numbers we need to deal with people with dementia,” he said.

However, Kennedy also thinks the projected number of Alzheimer’s patients contained in the new report may be too high. Baby boomers are healthier, more active, better educated and wealthier than their parents, he noted, and this may help delay the development of the disease until the end of their natural lifespan.

Also, new medications may make Alzheimer’s manageable by slowing its progression, Kennedy said.

“Probably within the next five years we’re going to have medications that alter the course of the illness,” he said. “When that happens, you’re going to see pushing back of the disability of the illness even further. So we don’t have to cure Alzheimer’s disease, we just have to find interventions that are going to delay the disability.”
HealthDay